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And perhaps most importantly, the rate of treatment discontinuation, which reveals how tolerable each treatment is in the real world rather than in the controlled environment of separate trials

To achieve sufficient glutamine, cancer cells must uptake glutamine from the extracellular environment through specific transporters on the cell membrane, such as the alanine-serine-cysteine transporter 2 (ASCT2), also known as SLCA15 (Scalise et al., 2017)